A replication-crisis tour-de-force with a masterful structure. Section I: a long, straight-faced literature review of the huge, highly-cited body of adult-neurogenesis research (its 'role' in memory, learning, depression, antidepressants, exercise, ECT, sex, music, even growth mindset — thousands of citations). Section II: the reveal — Sorrells et al (2018) find adult neurogenesis doesn't continue in adult humans (the subgranular zone isn't even a real structure). The analysis: how the field-wide error happened innocently (discovered in rats → assumed in humans → contamination-prone tests → confidence intervals included ~zero → the press ignored the species distinction; the synaptogenesis/neurogenesis confusion), the darker implication (if antidepressants/exercise/ECT work in humans, the 'neurogenesis mediates X' claims must be a massacre of false studies), the prosocial-studies observation (if we want to believe something, it accretes a protective layer of positive studies), the 'dogma' verbal-tic (over-learning from history → the opposite mistake), and the 'absolute terror' — the worst replication-crisis outbreak yet, in NEUROSCIENCE. ⚠ Scott's own epistemic-status header + Mistakes-page entry #20 note a LATER study contradicted the Sorrells 'no neurogenesis' finding — the central empirical claim is itself contested.

Quality 76 · Excellent. Excellent craft, DOCKED for the contested premise: a celebrated, masterfully-structured meta-science essay whose durable lessons (the prosocial-studies-accrete-evidence point, over-learning-from-dogma, the replication-crisis-in-neuroscience terror) stand regardless — but its 'massacre' news-hook rests on the Sorrells finding, which was subsequently contested (on Scott's Mistakes page), so docked from ~80 to 76 + Med conf. 76.

Claude’s paradigm shift 56 · Moderate. The literature-review-then-reveal structure + the durable meta-lessons; docked slightly for the contested premise. B56.

Real-world impact 2 · Minor. A much-cited replication-crisis essay; the meta-lessons get referenced (though the central claim was contested). RWI2.

Adult Neurogenesis – A Pointed Review